Professor Simon Leedham researches the morphogenic signalling pathways that control the intestinal stem cell in homeostasis, regeneration and cancer, and he has published more than 90 peer reviewed papers in journals that include Nature Medicine, Nature GeneticsCell Stem Cell, Gastroenterology and Gut. 

His work has been recognised by the United European Gastroenterology Rising Star award in 2010, the British Society of Gastroenterology Francis Avery Jones research prize in 2015 and the CRUK future leaders prize in 2017.

In 2012, Simon obtained an Honorary Consultant Gastroenterologist position in Oxford University Hospitals. He remains clinically active, completing one day of clinical practice a week and has established a gastroenterologist led family cancer clinic and endoscopy screening service in the hospital. He is also leading an Oxford Translational Gastroenterology Unit initiative to be the first unit in the country to offer universal patient consent, tissue and data collection from endoscopy.

Simon was Director of the CPM from 2016 to 2021.